Unless you are running a race fuel, when the engine is under load you will likely use timing in the middle to high teens at best.
If you are running a supercharged gas engine and not using a factory ECU with factory timing maps you would be far ahead of the game to get a J&S Vampire detonation detection and correction system. It can pick up the first instance of detonation and before the next ignition event pull timing on just the single cylinder that detonated, bringing it back half way for each successive ignition event until detonation is detected again. At the second detection it pulls back to the last known 'good' timing for that cylinder. It will do this for all eight cylinders simultaneously in real time.
If you run a modified blown gas engine this is not only the best protection available it also produces the maximum safe power possible. Here is a link to their site => J&S Electronics
It is not cheap and it actually works as described.